Sam Winchester:

- he's got demon blood

- he got possessed by lucifer

- he lost his soul (and his shoe)

- he saved the world

- he doesn't know how to live without his brother

- he died a lot

Dean Winchester:

- he went to hell and purgatory

- he's in love with an angel

- the Impala is Dean's baby

- he had the mark of Cain

- he saved the world

- he doesn't know how to live without his brother and his boyfriend

- he died a lot

Castiel:

- he's an angel of the lord

- he used to be a god

- he's in love with a human

- he saved the world

- he doesn't know how to live without the winchesters

- he died a lot